Treatment of spasticity using pulsed magnetic field in patients with multiple sclerosis

A double-blind, placebo-controlled trial

Nielsen J. F., Sinkjaer T., Jakobsen J., Department of Neurology, Aarhus University Hospital, Denmark

Spasticity is generally defined as increased myotonus - as resistance to passive stretching of a muscle, which increases with increasing speed of stretching. From the etiologic point of view, spinal cord injuries or degenerative diseases such as multiple sclerosis are the most common causes of spasticity. The effect of repetitive magnetic stimulation on spasticity was evaluated in 38 patients with multiple sclerosis in a double-blind, placebo-controlled trial. One group was treated with repetitive magnetic stimulation (n = 21) and the other group with placebo stimulation (n = 17). Both groups were treated twice a day for 7 consecutive days. The self-score of ease of daily activities improved by 22 % (P = 0.007) in the active group and by 29 % (P = 0.004) in the placebo group. The clinical spasticity score improved to -3.3 +/- 4.7 arbitrary unit (AU) in the active group and 0.7 +/- 2.5 AU in the placebo group (P = 0.003). The stretch reflex threshold increased to 4.3 +/- 7.5 deg/s in the active group and -3.8 +/- 9.7 deg/s in the placebo group (P = 0.001).

Conclusion: The data presented in this trial support the idea that repetitive magnetic stimulation has an antispastic effect in multiple sclerosis fatigue Multiple sclerosis and magnetic therapy.

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